COVID-19 el embarazo : eficacia del dímero D, ferritina y deshidrogenasa láctica como predictores de complicaciones

Abstract

SUMMARY Objective: To establish the relationship between the development of complications and changes in the concentrations of D-dimer, ferritin and lactic dehydrogenase, in a group of patients who are diagnosed with COVID-19 during pregnancy, at the Hospital Central de San Cristóbal, between August 2021 and February 2022. Methods: A retrospective, descriptive, correlational, cross-sectional study included 39 pregnant women diagnosed with COVID-19. The relationship between the marked and the evolution was evaluated. Results: The frequency of COVID-19 was 1.75 %, with a maternal mortality of 12.8 %. There were 16 (41%) complications, the most frequent was respiratory distress syndrome (12 pregnant women/30.8%). The disease was mild in 23 pregnant women (59%), moderate in 1 (2.5%) and severe in 15 (38.5%). Twenty-six patients (66.7%) had elevated D-dimer, with no association with COVID-19 complications. Eleven (28.2%) had elevated ferritin, this was associated with the development of hypokalemia (3 pregnant women/27.3%), admission to therapy (7 pregnant women/63.6%) and discharge conditions, including 4 of the 5 maternal deaths. Lactic dehydrogenase was elevated in 29 cases (74.4%), was associated with days of hospitalization and admission to therapy. With a ferritin cut-off point of 92 ng/dL, sensitivity of 81.3% and specificity of 73.9% were obtained to predict moderate-severe disease progression. Conclusion: Serum ferritin with cut-off values of 92 ng/dL was the most sensitive and specific biomarker as a predictor of complications.